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Disease Profile
Morning glory syndrome
Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.
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Age of onset
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ICD-10
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Inheritance
Autosomal dominant A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease.
Autosomal recessive Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype.
X-linked
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
X-linked
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
Mitochondrial or multigenic Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.
Multigenic or multifactor Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.
Not applicable
Other names (AKA)
Ectasic coloboma; Volubilis syndrome; Morning glory disc anomaly
Categories
Congenital and Genetic Diseases; Eye diseases
Summary
Morning glory
Symptoms include very poor vision in the affected eye with poor visual acuity. MGS may occur by itself or along with other eye abnormalities, such as
Treatment includes surgery and may result in some recovery of vision. Depending on the other associated abnormalities some patients require referrals to several specialties such as neurosurgery, interventional neuroradiology, otolaryngology, and dentistry. All people diagnosed with morning glory disc anomaly should have brain image exams.[3][4]
Symptoms
This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom.
Medical Terms | Other Names |
Learn More:
HPO ID
|
---|---|---|
80%-99% of people have these symptoms | ||
Abnormality of retinal pigmentation | 0007703 | |
Amblyopia |
Lazy eye
Wandering eye
[ more ] |
0000646 |
Cross-eyed
Squint
Squint eyes
[ more ] |
0000486 | |
5%-29% of people have these symptoms | ||
Clouding of the lens of the eye
Cloudy lens
[ more ] |
0000518 | |
Involuntary, rapid, rhythmic eye movements
|
0000639 | |
Optic nerve coloboma | 0000588 | |
Retinal detachment |
Detached retina
|
0000541 |
Related diseases
Related diseases are conditions that have similar signs and symptoms. A health care provider may consider these conditions in the table below when making a diagnosis. Please note that the table may not include all the possible conditions related to this disease.
Conditions with similar signs and symptoms from Orphanet
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The differential diagnoses include optic disc colobomas, staphylomas and amblyopia.
Visit the Orphanet disease page for more information.
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Learn more
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
Where to Start
- The American Academy of Ophthalmology Web site has an information page on Morning glory syndrome. Their Web site is dedicated to educating people about eye diseases and conditions and the preservation of eye health.
In-Depth Information
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Morning glory syndrome. Click on the link to view a sample search on this topic.
References
- Muslubas IS, Hocaoglu M, Arf S & Karacorlu M. A case of morning glory syndrome associated with persistent hyperplastic primary vitreous and Peters’ anomaly. GMS Ophthalmology Cases. 2017; 7:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5244077/.
- Morning Glory Syndrome. Orphanet. 2017; https://www.orpha.net/consor/cgi-bin/Disease_Search.php?lng=EN&data_id=10399.
- Strominger MB. Morning Glory Syndrome. American Academy of Ophthalmology. October 14, 2015; https://www.aao.org/pediatric-center-detail/neuro-ophthalmology-morning-glory-syndrome.
- Lytvynchuk LM, Glittenberg CG, Ansari-Shahrezaei S & Binder S. Intraoperative optical coherence tomography assisted analysis of pars Plana vitrectomy for retinal detachment in morning glory syndrome: a case report. BMC Ophthalmology. 2017; 17:134. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540621/.